VRK3 Inactive kinase that suppresses ERK action by announcement phosphatase action of DUSP3 which accurately dephosphorylates and inactivates ERK in the nucleus. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily. 2 animal isoforms produced by another splicing. Note: This description may cover advice from UniProtKB.
This gene encodes a affiliate of the vaccinia-related kinase (VRK) ancestors of serine/threonine protein kinases. In both animal and mouse, this gene has substitutions at several residues aural the ATP bounden motifs that in added kinases accept been apparent to be appropriate for catalysis. In vitro assays announce the protein lacks phosphorylation activity. The protein, however, acceptable retains its substrate bounden capability. This gene is broadly bidding in animal tissues and its protein localizes to the nucleus. Another splicing after-effects in assorted transcripts encoding altered isoforms.
The vaccinia-related kinase (VRK) proteins are a new accumulation of Ser/Thr kinases in the animal kinome. This beastly kinase ancestors comprises three members, VRK1, VRK2, and VRK3. The VRK1 has autophosphorylation action and phosphorylates several archetype factors, including p53, ATF2, and c-Jun. VRK2 is associated with the endoplasmic cloth. VRK3 suppresses Erk action through absolute alternation and activation of the MAP kinase phosphatase VHR. Further anatomic and structural assay of VRK proteins will annotate important new aspects of corpuscle regulation.
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