Preparation of 9-Fluorenol

9-Fluorenol is white crumb with its melting point 153-154 C (lit.) .It is stable, burnable but adverse with able acerbic agents. Its abstention is not beneath than 95% ( GC ) .The blueprint is 25G or 250G. the artefact of Plasmodium vivax beastly and asexual physique has accessible killing effect, has acceptable preventing aftereffect on Plasmodium vivax malaria. Aswell has killing aftereffect on abundant Plasmodium falciparum, but slow. Can lower claret gametophyte rate, inhibition of gametophyte development in mosquitoes. Shown in the chloroquine-resistant falciparum malaria ancient breadth of trial, the cure amount adjoin chloroquine or multidrug aggressive falciparum malaria in added than 95%. Compatibility with artemether, two antimalarial aftereffect can be complementary, lumefantrine insecticidal thoroughly, abiding effect, but ascendancy the affection of slow. And artemether available, but top acknowledgment rate. The beastly agreement proves, this toxicity is actual small, with no adverse reaction. This artefact is stored in a cool, dry place. Keep alembic bankrupt if not in use. Ablution thoroughly afterwards operation. Ablution easily afore eating. Remove attenuated clothing, ablution afore reuse. There are abundant blast using. Reduce dust bearing and accumulation. Avoid acquaintance with eyes, derma and clothing. Avoid assimilation and inhalation.

9-Fluorenol acclimated in medicine, dyes; constructed pesticides, herbicides; accomplish of amoebic bottle and fluorene aldehyde adhesive impact; acclimated as a wetting agent, detergent, antibacterial aqueous beam agent, etc.. Acclimated as the raw actual of amoebic synthesis. Can be fabricated of three nitro fluorenone, acclimated for electrostatic copying; amalgam of aryl cellophane nylon; instead of anthraquinone amalgam indanthrene dyes; acclimated in the accomplish of anticonvulsant, sedative, analgesic, abatement claret burden medicine; constructed pesticides, herbicides; alertness of amoebic bottle and fluorene aldehyde adhesive impact; bactericide can aswell be acclimated as a wetting agent, liquid, beam agent, disinfectant. In the high-temperature tar polyfluorene absolute about 1.0-2.0%. From ablution oil atom from 290-310 ℃fluorene atom beverage column, with the agnate of 115 abstract belfry bowl for absolute fractionation, the abatement arrangement of 15:1, 292-302℃cutting attenuated fraction. By cooling, crystallization, centrifugation, to access awkward fluorene, again 1:25 benzene or xylene recrystallization, accept automated fluorene. The automated fluorene acrid in benzene, ablution sulfuric acerbic 40%, followed by abatement and baptize washing, dissolving, the fluorene to distillation, the alcohol with gasoline and booze recrystallization, abstention is 95% authentic fluorene.

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