Methylmalonic acid, one of the chemicals. Metabolic processes such as propionic acid, thymine methyl malonyl CoA decomposition. The abridgement of vitamin B12 and methyl malonyl-CoA metabolism bedfast by the urine. Traits as acicular or bright crystals. The about body of 1.455. Mp 129 to 130 ° C. Solubility acrid in water, acrid in booze and ether.
Methylmalonic acid (MMA), is a dicarboxylic acid, a malonic acerbic ester acquired of the C - methylation. Of coenzyme A-linked anatomy of methyl malonic acid, methyl propionyl coenzyme A, is adapted into by methylpropionyloxy coenzyme A glycerate mutase, succinyl-CoA, the acknowledgment requires as a cofactor of vitamin B 12. In this manner, it enters the citric acerbic cycle, appropriately one of the allotment of the accoutrement reaction. The added levels of methylmalonic acerbic may announce that the abridgement of vitamin B 12. However, it is acute to the ache about consistently absolute analysis results, there is no specific analysis absolute do not consistently accept this disease. MMA animated in patients with 90-98% B 12 deficiency. It is not specific in 20-25% of patients over 70 years old accept animated levels of MMA, but 25-33% of the humans do not accept B 12 deficiency. For this reason, it is not recommended the accepted MMA analysis in the elderly.
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