Leukotriene E4 is a leukotriene. Leukotriene E4 (LTE4) is produced by the activity of dipeptidase on LTD4, abrogation alone the cysteinyl accumulation still absorbed to the blubbery acerbic backbone. It is one of the capacity of slow-reacting actuality of anaphylaxis (SRS-A). LTE4 is appreciably beneath alive (8 to 12-fold) than LTC4 in the biological activities appropriate of cysteinyl leukotrienes. Unlike LTC4 and LTD4, LTE4 accumulates in both claret and urine. Therefore, urinary elimination of LTE4 is generally acclimated as an indicator of asthma. In humans, basal levels of LTE4 ambit from 1-100 pg/mg creatinine. In asthmatic patients, urinary LTE4 levels access to 80-1,000 pg/mg creatinine.
LTE4 can also be considered a biomarker for asthma. LTE4, along with LTC4 and LTD4, are considered cysteinyl leukotrienes. They are products of arachidonic acid metabolism by the cyclooyxgenase 1/2 pathways. LTE4 is the stable end product of this pathway and can be measured. A number of studies have examined the level of LTE4 in exhaled breath condensate and urine in children with asthma.
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