This Human NTX ELISA kit is a ready-to-use 4-hour solid phase immunoassay capable of measuring NTX Blevels in serum, plasma, cell culture supernatant, tissue fluid and other biological fluids in the range of 0 to 2000 pg/mL. This assay has shown no cross-reactivity with various other cytokines super-family proteins, and is expected to be used effectively for further investigations into the relationship between Human NTX and various diseases.
In cartilage physiology, the N-terminal telopeptide (or added formally, amino-terminal collagen crosslinks, and accepted by the acronym NTX) is a biomarker acclimated to admeasurement the amount of cartilage turnover. NTX can be abstinent in the urine or serum.
Evaluating an individual's amount of cartilage turnover, termed cartilage remodeling, anon may be important in assessing his or her abeyant nonsurgical analysis acknowledgment as able-bodied as evaluating his or her accident of developing complications during healing afterward surgical intervention. To actuate an individual's amount of cartilage turnover, abundant biomarkers are accessible in the physique fluids that can be activated to this rate, and one such biomarker is NTX.
However, while NTX does alter in a actual acute address in band with cartilage absorption patterns, they are not actual specific, in that they may alter spontaneously after physiologic intervention. For example, NTX levels may bead by 50% from day to day with no treatment, thus, authoritative NTX levels bizarre affirmation of analysis effect.
Conversely, the serum CTX biomarker, declared in 2000 by Rosen, appears to be a abundant added able and admired indicator of cartilage absorption rate.
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