HDAC Assay Kits are 96-well plate-based assays to determine the HDAC (Histone Deacetylase) activity in your extracts or purified samples. Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. SwissProt: Q9UQL6 # Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions. Histone deacetylases act via the formation of lare multiprotein complexes. Involved in muscle maturation by repressing transcription. This assay is a simple two-step procedure performed in a microtiter plate.
HDAC Assay Kits are available in both colorimetric and fluorescent formats to suit your needs. Its original item name is Histone Deacetylase (HDAC) ELISA Kit. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein.
MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member. In the first step, samples are incubated with the HDAC assay substrate, allowing deacetylation of the substrate. Next, the Activator Solution releases p-nitroanilide from the deacetylated substrate or standard.
Specification: 96Test
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Wednesday, November 30, 2011
Tuesday, November 29, 2011
Phosphatidic Acidc ELISA Suppliers
Phosphatidic acid (PA) is a common phospholipid that is a major constituent of cell membranes. Phosphatidic acid is the smallest of the phospholipids. Synonyms: LPP3, VCIP, Dri42, PAP-2b, PAP2-b, MGC15306, PAP2-beta, Lpp3, Ppab2b, AV025606, D4Bwg0538e, D4Bwg1535e, 1110003O22Rik, 2610002D05Rik, ppap2ba, PPAP2B, ppap2b, LOC557680, MGC158309, MGC128313. Together these reactions constitute a signalling pathway that regulates water loss from plants. Research Unit “Molecular Cell Biology”, Klinikum der Friedrich-Schiller-Universit?t Jena, Drackendorfer Strasse 1, D-07747 Jena, Germany, and Institute of Medical Physics and Biophysics, Universit?t Leipzig, Liebigstrasse 27, D-04103 Leipzig, Germany
Phosphatidic acid is not an abundant lipid constituent of any living organism, but it is extremely important as an intermediate in the biosynthesis of triacylglycerols and phospholipids. Indeed, it is often over-estimated in tissues as it can arise by inadvertent enzymatic hydrolysis during inappropriate storage or extraction conditions during analysis. Phosphatidic acid is of considerable importance in cellular signalling in plants, for example in promoting pollen-tube growth, decreasing peroxide-induced cell death, and mediating the signalling processes that lead to responses to the plant hormone abscisic acid. Alternatives for Antigen "Phosphatidic Acid Phosphatase Type 2A (PPAP2A)", Type "Kits"
Product Code: E90975Pl
Pack Size: 96 Tests per Kit
Form: ELISA Kit
Target Species: Spinach
Product Type: ELISA Kits
Description: Detection range: 0.312-20 ng/ml
Spare 1: Sensitivity: 0.13 ng/ml
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Phosphatidic acid is not an abundant lipid constituent of any living organism, but it is extremely important as an intermediate in the biosynthesis of triacylglycerols and phospholipids. Indeed, it is often over-estimated in tissues as it can arise by inadvertent enzymatic hydrolysis during inappropriate storage or extraction conditions during analysis. Phosphatidic acid is of considerable importance in cellular signalling in plants, for example in promoting pollen-tube growth, decreasing peroxide-induced cell death, and mediating the signalling processes that lead to responses to the plant hormone abscisic acid. Alternatives for Antigen "Phosphatidic Acid Phosphatase Type 2A (PPAP2A)", Type "Kits"
Product Code: E90975Pl
Pack Size: 96 Tests per Kit
Form: ELISA Kit
Target Species: Spinach
Product Type: ELISA Kits
Description: Detection range: 0.312-20 ng/ml
Spare 1: Sensitivity: 0.13 ng/ml
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Monday, November 28, 2011
Phosphatidic Acidc ELISA for Sale
Phosphatidic acid (PA) is a common phospholipid that is a major constituent of cell membranes. Phosphatidic acid is the smallest of the phospholipids. Synonyms: LPP3, VCIP, Dri42, PAP-2b, PAP2-b, MGC15306, PAP2-beta, Lpp3, Ppab2b, AV025606, D4Bwg0538e, D4Bwg1535e, 1110003O22Rik, 2610002D05Rik, ppap2ba, PPAP2B, ppap2b, LOC557680, MGC158309, MGC128313. Together these reactions constitute a signalling pathway that regulates water loss from plants. Research Unit “Molecular Cell Biology”, Klinikum der Friedrich-Schiller-Universit?t Jena, Drackendorfer Strasse 1, D-07747 Jena, Germany, and Institute of Medical Physics and Biophysics, Universit?t Leipzig, Liebigstrasse 27, D-04103 Leipzig, Germany
Phosphatidic acid is not an abundant lipid constituent of any living organism, but it is extremely important as an intermediate in the biosynthesis of triacylglycerols and phospholipids. Indeed, it is often over-estimated in tissues as it can arise by inadvertent enzymatic hydrolysis during inappropriate storage or extraction conditions during analysis. Phosphatidic acid is of considerable importance in cellular signalling in plants, for example in promoting pollen-tube growth, decreasing peroxide-induced cell death, and mediating the signalling processes that lead to responses to the plant hormone abscisic acid. Alternatives for Antigen "Phosphatidic Acid Phosphatase Type 2A (PPAP2A)", Type "Kits"
Product Code: E90975Pl
Pack Size: 96 Tests per Kit
Form: ELISA Kit
Target Species: Spinach
Product Type: ELISA Kits
Description: Detection range: 0.312-20 ng/ml
Spare 1: Sensitivity: 0.13 ng/ml
More about: Buy Phosphatidic Acidc ELISA
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Phosphatidic acid is not an abundant lipid constituent of any living organism, but it is extremely important as an intermediate in the biosynthesis of triacylglycerols and phospholipids. Indeed, it is often over-estimated in tissues as it can arise by inadvertent enzymatic hydrolysis during inappropriate storage or extraction conditions during analysis. Phosphatidic acid is of considerable importance in cellular signalling in plants, for example in promoting pollen-tube growth, decreasing peroxide-induced cell death, and mediating the signalling processes that lead to responses to the plant hormone abscisic acid. Alternatives for Antigen "Phosphatidic Acid Phosphatase Type 2A (PPAP2A)", Type "Kits"
Product Code: E90975Pl
Pack Size: 96 Tests per Kit
Form: ELISA Kit
Target Species: Spinach
Product Type: ELISA Kits
Description: Detection range: 0.312-20 ng/ml
Spare 1: Sensitivity: 0.13 ng/ml
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Thursday, November 24, 2011
Poliomyelitis IgG ELISA kit Suppliers
Poliomyelitis is an infection caused by enterovirus, which occurs epidemically world-wide, and which often leads to paralysis and death.
Three types of human-pathogenic poliomyelitis viruses are actually known:
Type 1 (Brunhilde): often with severe symptoms
Type 2 (Lansing): with milder symptoms
Type 3 (Leon): rare, but with severe symptoms
Only recently a Poliomyelitis IgG ELISA assay was developed in analogy to Diphtheria and Tetanus, which can detect antibodies against the three types of Polio simultaneously. This serological response can be due to a past illness or to immunity by vaccination. Small volumes of Poliomyelitis virus IgG elisa kit may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Specification: 96Test
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Three types of human-pathogenic poliomyelitis viruses are actually known:
Type 1 (Brunhilde): often with severe symptoms
Type 2 (Lansing): with milder symptoms
Type 3 (Leon): rare, but with severe symptoms
Only recently a Poliomyelitis IgG ELISA assay was developed in analogy to Diphtheria and Tetanus, which can detect antibodies against the three types of Polio simultaneously. This serological response can be due to a past illness or to immunity by vaccination. Small volumes of Poliomyelitis virus IgG elisa kit may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice.
Specification: 96Test
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Wednesday, November 23, 2011
Free fatty acids (FFA) ELISA Suppliers
Fatty acids can be bound or attached to other molecules, such as in triglycerides or phospholipids. When they are not attached to other molecules, they are known as "free" fatty acids. The uncombined fatty acids or free fatty acids may come from the breakdown of a triglyceride into its components (fatty acids and glycerol). However as fats are insouble in water they must be bound to appropriate regions in the plasma protein albumin for transport around the body. The levels of "free fatty acid" in the blood are limited by the number of albumin binding sites available.
Free fatty acids are an important source of fuel for many tissues since they can yield relatively large quantities of ATP. Many cell types can use either glucose or fatty acids for this purpose. In particular, heart and skeletal muscle prefer fatty acids. The brain cannot use fatty acids as a source of fuel; it relies on glucose, or on ketone bodies. Ketone bodies are produced in the liver by fatty acid metabolism during starvation, or during periods of low carbohydrate intake. In chemistry, especially biochemistry, a fatty acid is a carboxylic acid often with a long unbranched aliphatic tail (chain), which is either saturated or unsaturated. Carboxylic acids as short as butyric acid (4 carbon atoms) are considered to be fatty acids, while fatty acids derived from natural fats and oils may be assumed to have at least 8 carbon atoms. It is also suggested that FFAs may act as ligands for cell-surface receptors because fatty acid derivatives, such as prostaglandins and leukotrienes, have their specific cell-surface G protein-coupled receptors (GPCRs).
Intended use
This immunoassay kit allows for the in vitro quantitative determination of human FFA concentrations in serum, plasma and other biological fluids.
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Free fatty acids are an important source of fuel for many tissues since they can yield relatively large quantities of ATP. Many cell types can use either glucose or fatty acids for this purpose. In particular, heart and skeletal muscle prefer fatty acids. The brain cannot use fatty acids as a source of fuel; it relies on glucose, or on ketone bodies. Ketone bodies are produced in the liver by fatty acid metabolism during starvation, or during periods of low carbohydrate intake. In chemistry, especially biochemistry, a fatty acid is a carboxylic acid often with a long unbranched aliphatic tail (chain), which is either saturated or unsaturated. Carboxylic acids as short as butyric acid (4 carbon atoms) are considered to be fatty acids, while fatty acids derived from natural fats and oils may be assumed to have at least 8 carbon atoms. It is also suggested that FFAs may act as ligands for cell-surface receptors because fatty acid derivatives, such as prostaglandins and leukotrienes, have their specific cell-surface G protein-coupled receptors (GPCRs).
Intended use
This immunoassay kit allows for the in vitro quantitative determination of human FFA concentrations in serum, plasma and other biological fluids.
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How to Buy IGFBP ELISA kit
IGFBPs can inhibit IGF actions, enhance IGF actions, or function independently as cell
regulatory factors. IGFBPs act as transporters of IGF, prolonging the life of IGF within
the body. Insulin-like growth factor (IGF) binding proteins (IGFBPs) play a pivotal role
in the regulation of IGF activity and availability in the circulation and extracellular
environment.
The IGFBP family has at least 6 members, which serve as transporter proteins and as
storage pools for IGF-1. All IGFBP family members are cysteine-rich proteins with high
binding affinity for IGF-I and IGF-II. IGFBP-3, the major IGF binding protein in plasma,
exists in a ternary complex with IGF-I or IGF-II and an acid-labile subunit (ALS). The
expressions of IGFBPs are tissue- and developmental stage–specific, and the
concentrations of IGFBPs in different body compartments are different.
The functions of IGFBPs are regulated by phosphorylation, proteolysis, polymerization, and cell or matrix
association of the IGFBP. Whereas the IGFBPs consistently have extremely high affinity
for IGF-1, the N-terminally truncated des-IGF-1 and a variety of IGF-1 analogues have
markedly reduced affinity for IGFBPs but retain normal affinity for IGF-1R.1 Moreover,
IGFBP-1 may play regulatory role inside of cells. It was reported that a portion of
intracellular IGFBP1 protein localizes to mitochondria where it binds to the
proapoptotic protein BAK and hinders BAK activation and apoptosis induction.
Interestingly, in many cells and tissues p53 also has a direct apoptotic function at
mitochondria that includes BAK binding and activation. When IGFBP1 is in a complex with
BAK, formations of a proapoptotic p53/BAK complex and apoptosis induction are impaired,
both in cultured cells and in liver. All 6 IGFBPs have been shown to inhibit IGF-1
action, but IGFBP-1, -3, and -5 are also shown to stimulate IGF-1 action. Some of IGFBPs
’ effects might be IGF-1 independent.
Specification: 96Test
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regulatory factors. IGFBPs act as transporters of IGF, prolonging the life of IGF within
the body. Insulin-like growth factor (IGF) binding proteins (IGFBPs) play a pivotal role
in the regulation of IGF activity and availability in the circulation and extracellular
environment.
The IGFBP family has at least 6 members, which serve as transporter proteins and as
storage pools for IGF-1. All IGFBP family members are cysteine-rich proteins with high
binding affinity for IGF-I and IGF-II. IGFBP-3, the major IGF binding protein in plasma,
exists in a ternary complex with IGF-I or IGF-II and an acid-labile subunit (ALS). The
expressions of IGFBPs are tissue- and developmental stage–specific, and the
concentrations of IGFBPs in different body compartments are different.
The functions of IGFBPs are regulated by phosphorylation, proteolysis, polymerization, and cell or matrix
association of the IGFBP. Whereas the IGFBPs consistently have extremely high affinity
for IGF-1, the N-terminally truncated des-IGF-1 and a variety of IGF-1 analogues have
markedly reduced affinity for IGFBPs but retain normal affinity for IGF-1R.1 Moreover,
IGFBP-1 may play regulatory role inside of cells. It was reported that a portion of
intracellular IGFBP1 protein localizes to mitochondria where it binds to the
proapoptotic protein BAK and hinders BAK activation and apoptosis induction.
Interestingly, in many cells and tissues p53 also has a direct apoptotic function at
mitochondria that includes BAK binding and activation. When IGFBP1 is in a complex with
BAK, formations of a proapoptotic p53/BAK complex and apoptosis induction are impaired,
both in cultured cells and in liver. All 6 IGFBPs have been shown to inhibit IGF-1
action, but IGFBP-1, -3, and -5 are also shown to stimulate IGF-1 action. Some of IGFBPs
’ effects might be IGF-1 independent.
Specification: 96Test
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Monday, November 21, 2011
HLA-B27 ELISA Kit for Sale
Human Leukocyte Antigen B27 is a class I surface antigen encoded by the B locus in the major histocompatibility complex (MHC) on chromosome 6 and presents microbial antigens to T-cells. HLA-B27 is strongly associated with a certain set of autoimmune diseases referred to as the seronegative spondyloarthropathies. In the general population, about 8% Caucasian, 4% African, 2-9% Chinese, and 0.1-0.5% Japanese have the HLA-B27 antigen. In Northern Scandinavia (Lapland), 24% of people are HLA-B27 positive while 1.8% have ankylosing spondylitis (AS). The relationship between HLA-B27 and many diseases has not yet been fully elucidated. Though it is associated with a wide range of pathology, it does not appear to be the sole mediator in development of disease.
Specification:96Test
Characteristics: This immunoassay kit allows for the in vitro quantitative determination of human HLA-B27 concentrations in cell culture supernates, serum, plasma and other biological fluids.
Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
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Specification:96Test
Characteristics: This immunoassay kit allows for the in vitro quantitative determination of human HLA-B27 concentrations in cell culture supernates, serum, plasma and other biological fluids.
Preparation and Storage: Unopened test kits should be stored at 2 to 8 degree C upon receipt. Please refer to pdf manual for further storage instructions.
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Sunday, November 20, 2011
What is TIMP-2 ELISA Kit
TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa produced by a wide range of cell types. The biological activities of proteases are subject to a complex regulation also involving specific inhibitors which called TIMP (Tissue inhibitor of metalloproteinases ).
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF. It inhibits MMPs non-covalently by the formation of binary complexes.
This gene is a member of the TIMP gene family. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Specification:96test
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TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF. It inhibits MMPs non-covalently by the formation of binary complexes.
This gene is a member of the TIMP gene family. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
Specification:96test
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Saturday, November 19, 2011
What is CCP ELISA Kit and Its Usage
Anti-CCP, which stands for anti-cyclic citrullinated peptide antibody, is a new and exciting blood test to help doctors confirm a diagnosis of rheumatoid arthritis. Rheumatoid Arthritis (RA), a chronic inflammatory disorder of the synovial membranes, is one of the most common systemic autoimmune diseases. This immunoassay kit allows for the in vitro quantitative determination of human anti-CCP concentrations in serum, plasma and other biological fluids. Early diagnosis of RA is important both in disease treatment and management. Approximately 1% of the world population is affected. The diagnosis of RA depends primarily on clinical manifestations, but laboratory results are helpful in differential diagnosis and disease management.
Historically, rheumatoid factor (RF) has long been the serologic indicator for RA. However, it has been known for years that anti-keratin autoantibodies (AKA), also known as anti-perinuclear autoantibodies, are detected in 40-55% of RA patients and in 40-50% of clinically diagnosed RA patients who are RF negative.
Specification: 96test.
How to Use CCP ELISA Kit
When mixing or reconstituting protein solutions, always avoid foaming. To avoid cross-contamination, change pipette tips between additions of each standard level, between sample additions, and between reagent additions.
2.used to separate reservoirs for each reagent. When using an automated plate washer, adding a 30 second soak period following the addition of wash buffer, and/or rotating the plate 180 degrees between wash steps may improve assay precision.
3.To ensure accurate results, proper adhesion of plate sealers during incubation steps is necessary. Substrate Solution should remain colorless until added to the plate. Keep Substrate Solution protected from light. Substrate Solution should change from colorless to gradations of blue.
4.Stop Solution should be added to the plate in the same order as the Substrate Solution. The color developed in the wells will turn from blue to yellow upon addition of the Stop Solution. Wells that are green in color indicate that the Stop Solution has not mixed thoroughly with the Substrate Solution.
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Historically, rheumatoid factor (RF) has long been the serologic indicator for RA. However, it has been known for years that anti-keratin autoantibodies (AKA), also known as anti-perinuclear autoantibodies, are detected in 40-55% of RA patients and in 40-50% of clinically diagnosed RA patients who are RF negative.
Specification: 96test.
How to Use CCP ELISA Kit
When mixing or reconstituting protein solutions, always avoid foaming. To avoid cross-contamination, change pipette tips between additions of each standard level, between sample additions, and between reagent additions.
2.used to separate reservoirs for each reagent. When using an automated plate washer, adding a 30 second soak period following the addition of wash buffer, and/or rotating the plate 180 degrees between wash steps may improve assay precision.
3.To ensure accurate results, proper adhesion of plate sealers during incubation steps is necessary. Substrate Solution should remain colorless until added to the plate. Keep Substrate Solution protected from light. Substrate Solution should change from colorless to gradations of blue.
4.Stop Solution should be added to the plate in the same order as the Substrate Solution. The color developed in the wells will turn from blue to yellow upon addition of the Stop Solution. Wells that are green in color indicate that the Stop Solution has not mixed thoroughly with the Substrate Solution.
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Thursday, November 17, 2011
Hydroxy pyridinium crosslinks ELISA Kit for Sale
The Hydroxypyridinium Crosslinks HPLC Assay kit is for research use only and not to be
used in diagnostic procedures. It is used in health products, medical products
manufacture and drug making and is intended for the quantitative determination of the
hydroxy-pyridinium crosslinks in urine.
Product description:
Specification:96Test
The hydroxypyridinium compounds pyridinoline (PYD) and deoxypyridinoline (DPD) are
specific constituents of mature skeletal collagens. Their measurement in urine is a
sensitive index of the extent of ongoing bone resorption. They are released into the
circulation and excreted in the urine. The quantification of collagen Crosslinks in
urine is achieved by chromatographic techniques.
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used in diagnostic procedures. It is used in health products, medical products
manufacture and drug making and is intended for the quantitative determination of the
hydroxy-pyridinium crosslinks in urine.
Product description:
Specification:96Test
The hydroxypyridinium compounds pyridinoline (PYD) and deoxypyridinoline (DPD) are
specific constituents of mature skeletal collagens. Their measurement in urine is a
sensitive index of the extent of ongoing bone resorption. They are released into the
circulation and excreted in the urine. The quantification of collagen Crosslinks in
urine is achieved by chromatographic techniques.
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Tuesday, November 15, 2011
YKL- 40 Elisa (96 wells) kits for Sale
YKL-40 It is also named human cartilage glycoprotein 39 (HC gp-39). It has both heparin and chitin binding domains and appears to be an autoantigen in rheumatoid arthritis. serum YKL-40 is investigated a new marker for cancer. This 40 KD glycoprotein and its production by osteosarcoma cells (MG-63), neutrophils, chondrocytes, synovial cells, and activated macrophages was reported. It is associated in many cancers studied to date, including cancer of the colon, lung, prostate, ovary, and breast.
It has both heparin and chitin binding domains and appears to be an autoantigen in rheumatoid arthritis.
Recently, serum YKL-40 has been investigated as a new marker for cancer. Elevated serum YKL-40 is associated in many cancers studied to date, including cancer of the colon, lung, prostate, ovary, and breast.
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It has both heparin and chitin binding domains and appears to be an autoantigen in rheumatoid arthritis.
Recently, serum YKL-40 has been investigated as a new marker for cancer. Elevated serum YKL-40 is associated in many cancers studied to date, including cancer of the colon, lung, prostate, ovary, and breast.
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What is Anti-SRF(Serum response factor)
Serum response factor (SRF) is a cardiac enriched transcription factor that is required
for the appearance of beating sarcomeres in the heart. It is a transcription factor
that binds the serum response element (SRE), a sequence that mediates the transient
response of many cellular genes to growth stimulation. In addition, SRF may also direct
the expression of microRNAs that inhibit the expression of cardiac regulatory factors.
SRF binding sites are also constitutive promotor elements in many muscle specific
promoters. Two related Ets domain proteins, Elk 1 and SRF accessory protein 1 (SAP 1)
have DNA binding properties identical to that of it. The formation of a ternary complex
containing SRF and its accessory protein appears to be important for signal
transduction. This gene encodes a ubiquitous nuclear protein that stimulates both cell
proliferation and differentiation. It is a member of the MADS (MCM1, Agamous,
Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the
serum response element (SRE) in the promoter region of target genes. This gene is the
downstream target of many pathways; this protein regulates the activity of many
immediate-early genes, for example c-fos, and thereby participates in cell cycle
regulation, apoptosis, cell growth, and cell differentiation.
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for the appearance of beating sarcomeres in the heart. It is a transcription factor
that binds the serum response element (SRE), a sequence that mediates the transient
response of many cellular genes to growth stimulation. In addition, SRF may also direct
the expression of microRNAs that inhibit the expression of cardiac regulatory factors.
SRF binding sites are also constitutive promotor elements in many muscle specific
promoters. Two related Ets domain proteins, Elk 1 and SRF accessory protein 1 (SAP 1)
have DNA binding properties identical to that of it. The formation of a ternary complex
containing SRF and its accessory protein appears to be important for signal
transduction. This gene encodes a ubiquitous nuclear protein that stimulates both cell
proliferation and differentiation. It is a member of the MADS (MCM1, Agamous,
Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the
serum response element (SRE) in the promoter region of target genes. This gene is the
downstream target of many pathways; this protein regulates the activity of many
immediate-early genes, for example c-fos, and thereby participates in cell cycle
regulation, apoptosis, cell growth, and cell differentiation.
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Wednesday, November 9, 2011
Anti-DBH (Dopamine-β-Hydroxylase) for Sale
Dopamine β-hydroxylase (DBH) is an enzyme that converts dopamine to
norepinephrine.
DBH is the only enzyme involved in the synthesis of small-molecule
neurotransmitters that is membrane-bound, making norepinephrine and epinephrine
the only transmitters synthesized inside vesicles. It is a 290 kDa copper-
containing oxygenase consisting of four identical subunits, and its activity
requires ascorbate as a cofactor. It is expressed in noradrenergic nerve
terminals of the central and peripheral nervous systems, as well as in chromaffin
cells of the adrenal medulla.
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norepinephrine.
DBH is the only enzyme involved in the synthesis of small-molecule
neurotransmitters that is membrane-bound, making norepinephrine and epinephrine
the only transmitters synthesized inside vesicles. It is a 290 kDa copper-
containing oxygenase consisting of four identical subunits, and its activity
requires ascorbate as a cofactor. It is expressed in noradrenergic nerve
terminals of the central and peripheral nervous systems, as well as in chromaffin
cells of the adrenal medulla.
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Tuesday, November 8, 2011
How to Buy Anti-DCC (Deleted in colorectal cancer gene)
Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. While the official, full name of this gene is Deleted in Colorectal Carcinoma,it is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.
DCC has been characterized as a dependence receptor, and theories have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically sile.
Read more: http://www.metallochemistry.com/
DCC has been characterized as a dependence receptor, and theories have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically sile.
Read more: http://www.metallochemistry.com/
Monday, November 7, 2011
How to Buy Anti-DCC (Deleted in colorectal cancer gene)
Deleted in Colorectal Carcinoma, also known as DCC, is a protein which in humans is encoded by the DCC gene. DCC has long been implicated in colorectal cancer. It is almost universally called Deleted in Colorectal Cancer. The protein product of DCC is a single transmembrane receptor also known as DCC, and it has the same interchangeable name.
DCC has been characterized as a dependence receptor, and theories have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.
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Elisa assay kits
DCC has been characterized as a dependence receptor, and theories have been put forward that have revived interest in DCC's candidacy as a tumour suppressor gene, as it may be a ligand-dependent suppressor that is frequently epigenetically silenced.
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Sunday, November 6, 2011
Anti-DCP for Sale
DCP is a nonfunctional prothrombin resulting from a lack of carboxylation of 10 glutamic acid residues in the N-terminal portion of the molecule. In normal prothrombin, a precursor undergoes post-translational carboxylation in the liver before release into the peripheral blood. The vitamin K dependent carboxylase responsible is absent in many HCC cells, which secrete the noncarboxylated form, DCP.
Read more: Elisa assay kits
Read more: Elisa assay kits
Thursday, November 3, 2011
How to Buy Anti-DCX(Doublecortin)
Doublecortex; lissencephaly, X-linked (doublecortin), also
known as DCX, is a gene.
Doublecortin (DCX) is a microtubule-associated protein
expressed by neuronal precursor cells and immature neurons
in embryonic and adult cortical structures. Neuronal
precursor cells begin to express DCX while actively
dividing, and their neuronal daughter cells continue to
express DCX for 2-3 weeks as the cells mature into neurons.
Downregulation of DCX begins after 2 weeks, and occurs at
the same time that these cells begin to express, NeuN, a
marker for mature neurons.
Due to the nearly exclusive expression of DCX in developing
neurons, this protein has been used increasingly as a
marker for neurogenesis. Indeed, the levels of DCX
expression increase in response to exercise,which occurs in
parallel with increased BrdU labelling, currently a "gold
standard" in measuring neurogenesis.
Read more: Elisa assay kits
known as DCX, is a gene.
Doublecortin (DCX) is a microtubule-associated protein
expressed by neuronal precursor cells and immature neurons
in embryonic and adult cortical structures. Neuronal
precursor cells begin to express DCX while actively
dividing, and their neuronal daughter cells continue to
express DCX for 2-3 weeks as the cells mature into neurons.
Downregulation of DCX begins after 2 weeks, and occurs at
the same time that these cells begin to express, NeuN, a
marker for mature neurons.
Due to the nearly exclusive expression of DCX in developing
neurons, this protein has been used increasingly as a
marker for neurogenesis. Indeed, the levels of DCX
expression increase in response to exercise,which occurs in
parallel with increased BrdU labelling, currently a "gold
standard" in measuring neurogenesis.
Read more: Elisa assay kits
Wednesday, November 2, 2011
Anti--HCMV PP65/HHV5 PP65 for Sale
Cytomegalovirus is a herpes viral genus of the Herpesviruses group: in humans it is commonly known as HCMV or Human Herpesvirus 5 (HHV-5).CMV belongs to the Betaherpesvirinae subfamily of Herpesviridae, which also includes Roseolovirus.
HCMV is also the virus most frequently transmitted to a developing fetus. HCMV infection is more widespread in developing countries and in communities with lower socioeconomic status and represents the most significant viral cause of birth defects in industrialized countries. CMV "seems to have a large impact on immune parameters in later life and may contribute to increased morbidity and eventual mortality.
Read more: Elisa assay kits
HCMV is also the virus most frequently transmitted to a developing fetus. HCMV infection is more widespread in developing countries and in communities with lower socioeconomic status and represents the most significant viral cause of birth defects in industrialized countries. CMV "seems to have a large impact on immune parameters in later life and may contribute to increased morbidity and eventual mortality.
Read more: Elisa assay kits
How to Get Anti-CXC-R3/CD183
Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183.
CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation.
Read more: Elisa assay kits
CXCR3 is able to regulate leukocyte trafficking. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation.
Read more: Elisa assay kits
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