TIMP-2 is a non N-glycosylated protein with a molecular mass of 22 kDa produced by a wide range of cell types. The biological activities of proteases are subject to a complex regulation also involving specific inhibitors which called TIMP (Tissue inhibitor of metalloproteinases ).
TIMP metallopeptidase inhibitor 2, a tissue inhibitor of metalloproteinases, also known as TIMP2, is a human gene, thought to be a metastasis suppressor. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In melanocytic cells TIMP2 gene expression may be regulated by MITF. It inhibits MMPs non-covalently by the formation of binary complexes.
This gene is a member of the TIMP gene family. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix.
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