YKL-40 It is also named human cartilage glycoprotein 39 (HC gp-39). It has both heparin and chitin binding domains and appears to be an autoantigen in rheumatoid arthritis. serum YKL-40 is investigated a new marker for cancer. This 40 KD glycoprotein and its production by osteosarcoma cells (MG-63), neutrophils, chondrocytes, synovial cells, and activated macrophages was reported. It is associated in many cancers studied to date, including cancer of the colon, lung, prostate, ovary, and breast.
It has both heparin and chitin binding domains and appears to be an autoantigen in rheumatoid arthritis.
Recently, serum YKL-40 has been investigated as a new marker for cancer. Elevated serum YKL-40 is associated in many cancers studied to date, including cancer of the colon, lung, prostate, ovary, and breast.
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