Doublecortex; lissencephaly, X-linked (doublecortin), also
known as DCX, is a gene.
Doublecortin (DCX) is a microtubule-associated protein
expressed by neuronal precursor cells and immature neurons
in embryonic and adult cortical structures. Neuronal
precursor cells begin to express DCX while actively
dividing, and their neuronal daughter cells continue to
express DCX for 2-3 weeks as the cells mature into neurons.
Downregulation of DCX begins after 2 weeks, and occurs at
the same time that these cells begin to express, NeuN, a
marker for mature neurons.
Due to the nearly exclusive expression of DCX in developing
neurons, this protein has been used increasingly as a
marker for neurogenesis. Indeed, the levels of DCX
expression increase in response to exercise,which occurs in
parallel with increased BrdU labelling, currently a "gold
standard" in measuring neurogenesis.
Read more: Elisa assay kits
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