Specific for digoxin and Reacts with Digitoxin. Digoxin is a glycoside extracted from the foxglove plant Digitalis lanata. Its primary mechanism of action is to inhibit alpha subunits of the Na+/K+ ATPase pump located in the plasma membrane of human myocytes. This inhibition leads to an increase in intracellular calcium concentration and an increase in myocardial contraction. Digoxin also results in a decrease of electrical impulse conduction through the AV node. Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and atrial tachycardia.
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Immunoglobulin G (IgG) are antibody molecules. Each IgG is composed of four peptide chains — two heavy chains γ and two light chains. Each IgG has two antigen binding sites. Other immunoglobulins may be described in terms of polymers with the IgG structure considered the monomer. IgG antibodies are involved in predominantly the secondary immune response. The presence of specific IgG, in general, corresponds to maturation of the antibody response. Digoxin is widely used in the treatment of various heart conditions, namely atrial fibrillation, atrial flutter and atrial tachycardia. IgG constitutes 75% of serum immunoglobulins in humans. IgG antibodies are large molecules of about 150 kDa composed of four peptide chains. IgG molecules are synthesized and secreted by plasma B cells.
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