Anti-FAS/Apo-a1/CD95 is mainly used for various malignant tumor (including: breast cancer, renal cell carcinoma, stomach, lung, and liver disease) research. Molecular weight is: 40-50 kDa.
The Fas receptor (FasR) is a death receptor connected the Earth's surface of cubicles that contributes to programmed cell death (apoptosis). It embodies unitary of cardinal programmed cell death pathways. The other than living the mitochondrial pathway. FasR is also known as CD95, Apo-1, and tumor necrosis constituent sensory receptor superfamily, appendage sextet (TNFRSf6). Apolipoprotein A1 antibodies. FasR equals located on chromosome 10 at humans and 19 fashionable mice. Similar sequences colligated near phylogenesis (orthologs) are discovered incoming to the highest degree mammals.
The apoptotic signals is mainly FAS through its cytoplasm area related death mediated FADD protein structure domain. Combining with FasL FAS, FADD hand through the C with the DD FAS, on the other hand, Anti-FAS/Apo-a1/CD95 by the N DED Caspase-8 N and the combination DED, through the Caspase-8 induction effect of activation Caspase protease, and finally result in cell apoptosis happen. FAS mainly express to activate the lymphocytes and mononuclear cells and neutrophils and fibroblasts, etc.
FAS (also called Apo-1; CD95; FasL receptor; TNFR) is a contain death receptor structure domain, is type membrane protein, belongs to the TNF-R family members, have the function of apoptosis, widely distributed in many different types of cells.
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