Collagen-Type-I ELISA is the most abundant form of collagen in the human body and is synthesized mainly by fibroblasts, osteoblasts, odontoblasts and chondroblasts. It is located in the extracellular matrix of many tissues of the body including cartilage, bone, tendon, skin and the sclera of the eye. The formation of cross-links results in very strong type I collagen fibrils, which are found in the spaces around cells. Collagen Type I is involved in many human diseases such as fibrosis, osteoporosis, cancer and atherosclerosis.
Collagen has great tensile strength, and is the main component of fascia, cartilage, ligaments, tendons, grind away and pelt. Along with soft keratin, it is creditworthy because pare intensity level and elasticity, and its degradation leads to wrinkles that accompany aging. It strengthens bloodshed vessels and capers a persona incoming tissue development. It is present in the cornea and lens of the eye in crystalline form. It is also used in cosmetic surgery and cauterises surgical procedure. Hydrolyzed collagen give notice child's play an important role in weight management, since a protein, it give notice equal advantageously ill-used for its satiating power.
Type I collagen is composed of two pro-α1(I) chains, produced from the COL1A 1 gene, and one pro-α2(I) chain, produced from the COL1A 2 gene. Mutations in the genes that produce collagen type I are responsible for causing various health conditions including Ehlers-Danlos syndrome, osteogenesis imperfecta, osteoporosis and Caffey disease.
This kit is designed to quantify collagen in various sources such as cell media, ECM (Extra Cellular Matrix) of culture cell and tissue because the kit detects atelo-collagen which is prepared by pepsin digestion.
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