Chemokine receptor CXCR3 is a Gαi protein-coupled receptor in the CXC chemokine receptor family. Other names for CXCR3 are G protein-coupled receptor 9 (GPR9) and CD183.
CXCR3 is able to regulate leukocyte trafficking.
CXCR3 is a receptor for CXCL9, CXCL10 and CXCL11 and mediates the proliferation of human mesangial cells (HumanC). Isoform 2 is a receptor for CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the growth of human microvascular endothelial cells (HumanVEC).
synthetic peptide corresponding to the C-terminus of human CXC chemokine receptor 3 (CXCR3), conjugated to KLH. The immunizing peptide has 82% homology with the rat and mouse gene.
Neutralization (ND50): ~0.3-1.5ug/ml in the presence of 7ng/ml of Recombinant human CXCL11/l-TAC, using the hCXCR3 transfected BaF/3 cells in a chemotaxis assay. Isoform 2 may play a role in angiogenesis. Isoform 3 mediates activity of CXCL11. Binding of chemokines to CXCR3 induces various cellular responses, most notably integrin activation, cytoskeletal changes and chemotactic migration. CXCR3-ligand interaction attracts Th1 cells and promotes Th1 cell maturation. Mouse myeloma with B cells obtained from a mouse inoculated with human CXCR3 transfected NS0 mouse myeloma cells.
More about: Anti-CXC-R3/CD183
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