The protein encoded by Anti-P-p38 ERK/MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, recording regularization and exploitation.
Specific combination antigen: antibody itself cannot direct dissolve or killer with a specific antigen to target cells, usually need to complement or phagocytic cells together to clear the effect of pathogenic microorganisms or lead to pathological damage. However, with the virus antibodies can be or poison the specificity of the union, and the role of the virus directly play.
This kinase equals sparked off by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase.
The substrates of this kinase include transcription regulator ATF2, MEF2C , and MAX, cellular telephone cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four as an alternative spliced transcript discrepancies of this gene cyphering distinguishable isoforms have been reported.
More information: Anti-P-p38 ERK/MAPK14
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