For the quantitative determination of human 0-FQ concentrations in serum, plasma,cell culture supernates and tissue homogenate.
The kit is a competitive inhibition enzyme immunoassay technique for the in vitro quantitative measurement of Mouse Orphanin FQ (OFQ) in serum, plasma and other biological fluids.
Orphanin FQ (or Nociceptin ) is the endogenous ligand for the nociceptin receptor. Nociceptin is thought to be an endogenous antagonist of dopamine transport that may act either directly on dopamine or by inhibiting GABA to affect dopamine levels. Within the central nervous system its action can be either similar or opposite to those of opioids depending on their location. It controls a wide range of biological functions ranging from nociception to food intake, from memory processes to cardiovascular and renal functions, from spontaneous locomotor activity to gastrointestinal motility, from anxiety to the control of neurotransmitter release at peripheral and central sites.
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