What is U-Calcitonin ELISA Kit?

Calcitonin, a 32-amino-acid polypeptide, is buried primarily by the thyroidal parafollicular C-cells. Its capital biological aftereffect is to arrest osteoclastic cartilage absorption as able-bodied as arena a role in calcium and phosphorus metabolism in the cartilage and kidney. Calcitonin supresses absorption of cartilage by inhibiting the action of osteoclasts absolution calcium and phosphorus into blood. In the kidney, calcium and phosphorus are prevented from getting absent in urine by reabsorption in the branch tubules. Calcitonin inhibits tubular reabsorption of these two ions, arch to added ante of their accident in urine.
Calcitonin is a 32-amino acerbic beeline polypeptide hormone that is produced in bodies primarily by the parafollicular beef (also accepted as C-cells) of the thyroid, and in abounding added animals in the ultimobranchial body. It acts to abate claret calcium (Ca2+), opposing the furnishings of parathyroid hormone (PTH). Calcitonin has been begin in fish, reptiles, birds, and mammals. Its accent in bodies has not been as able-bodied accustomed as its accent in added animals, as its action is usually not cogent in the adjustment of accustomed calcium homeostasis.. It belongs to calcitonin-like protein family.
Calcitonin was extracted from the Ultimobranchial glands (thyroid-like glands) of fish, particularly salmon. Salmon calcitonin resembles human calcitonin, but is more active. At present, it is produced either by recombinant DNA technology or by chemical peptide synthesis. The pharmacological properties of the synthetic and recombinant peptides have been demonstrated to be qualitatively and quantitatively equivalent.
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