Nerve advance factor (NGF) is one of a ancestors of neurotrophins that abet the adaptation and admeasurement of neurons. In corpuscle culture, NGF induces the accumulation of neurite projections and, in vivo, may activate the action of tissues. NGF plays a role in the repair, regeneration, and aegis of neurons, and as such could serve as a ameliorative abettor in neurodegenerative altitude such as Alzheimer's disease. NGF enhances survival, growth, neurotransmitter biosynthesis of affectionate and acoustic neurons; neurotrophic factor; cutaneous innervation; growth, adverse and adaptation of B lymphocytes. It aswell has a accessible role in abhorrence and tissue repair. NGF is begin in the hypothalamus, pituitary, thyroid gland, testes, epididymis, vascular bland beef cells, fibroblasts, mast beef and eosinophils. NGF is upregulated by glutamate, vitamin D3, IL6, FGF basic, astrocyte specific IL1, TNF alpha, PDGF and TGF beta. It is downregulated by GABAergic neuronal activity, glucocorticoids and Schwann cell-specific TGF beta.
Application Notes:
Immunohistochemistry Analysis: A 1:50-100 concoction from a antecedent lot detected NGFβ in animal academician tissue.
Immunocytochemistry Analysis: A 1:100-250 concoction from a antecedent lot was acclimated in IC.
Usage Statement
Unless contrarily declared in our archive or added aggregation affidavit accompanying the product(s), our articles are advised for analysis use alone and are not to be acclimated for any added purpose, which includes but is not bound to, crooked bartering uses, in vitro analytic uses, ex vivo or in vivo ameliorative uses or any blazon of burning or appliance to bodies or animals.
Applications
Western Blotting
Immunohistochemistry (Paraffin)
Immunocytochemistry
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