This immunoassay allows for the in vitro quantitative determination of human SC concentrations in serum, plasma and other biological fluids.
Description
The secretory component is a component of immunoglobulin A (IgA) which consists of a portion of the polymeric immunoglobulin receptor. Polymeric IgA binds to the polymeric immunoglobulin receptor on the basolateral surface of epithelial cells and is taken up into the cell via transcytosis. The receptor-IgA complex passes through the cellular compartments before being secreted on the luminal surface of the epithelial cells, still attached to the receptor. Proteolysis of the receptor occurs and the dimeric IgA molecule, along with the secretory component, are free to diffuse throughout the lumen.
Specificity
SCC ELISA Kit recognizes recombinant and natural human SC. No significant cross-reactivity or interference was observed.
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