What is Anti-Lgr5/GPR49?

Lgr5 (Leucine-rich repeat G protein-coupled receptor 5) is thought of as a possible stem cell marker for the hair follicle and the epithelium of the intestine. LGR5 is only expressed in cycling crypt base columnar cells, which are thought to be genuine intestinal stem cells. LGR5 has also been implicated as a negative regulator of the Wnt signaling pathway. LGR5 is often up-regulated in certain cancers and may play a role in cancer cell progression.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
FUNCTION: Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
Specificity:
This antibody recognizes LRG5 at the cytoplasmic domain.
Format of Anti-Lgr5/GPR49
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
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